Recent approaches have explored concomitantly targeting multiple surface receptors with single nanoparticle systems conjugated with multiple ligands [53]. Nanotechnology is often touted as one of the most promising drug delivery innovations in today's fight against cancer. In vivo studies of MUC1 aptamer-capped mesoporous silica nanomaterials on MDA-MB-231 tumor-bearing Balb/c mice were found to effectively target breast cancer cells and induce a dramatic reduction in cell viability [223]. Biophys. Formulations have been approved for the treatment of Kaposis sarcoma, acute lymphoblastic leukemia, pancreatic cancer, ovarian cancer, multiple myeloma and metastatic breast cancer including Doxil, Myocet, DaunoXome, DepoCyte, Lipoplatin. 53(46), 1232012364 (2014), J. Yue et al., Gold nanoparticle size and shape effects on cellular uptake and intracellular distribution of siRNA nanoconstructs. 24(48), 64336437 (2012), P. Shi et al., pH-responsive NIR enhanced drug release from gold nanocages possesses high potency against cancer cells. Cancer is one of the leading causes of death and morbidity with a complex pathophysiology. Fan et al., Thermoresponsive supramolecular chemotherapy by V-shaped armed -cyclodextrin star polymer to overcome drug resistance. Today 19(3), 157168 (2016), A. Bajaj et al., Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Negative Impact on Environment: With the advance of nanotechnology pollution has also been increased due to the nanoparticle produced during the making of various drugs, atomic bombs, etc. The in vivo antitumor studies suggested that the tumor volume drastically reduced in mice in the presence of magnetic nanocarrier, magnet and laser. Cell Biochem. Cancer 17, 20 (2016), B. Ruozi et al., PLGA nanoparticles loaded cerebrolysin: studies on their preparation and investigation of the effect of storage and serum stability with reference to traumatic brain injury. Control. Patil et al., Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery. Active targeting, therefore, relies extensively on endoplasmic retention effects to reach the targets. Nanomaterials 8(4), 193 (2018), X. Liu et al., Targeted delivery of SNX-2112 by polysaccharide-modified graphene oxide nanocomposites for treatment of lung cancer. Cancer Res. Mater. Navya, A. Kaphle, H.K. Yadav, S.C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems. These nanoparticles can be customized for various biomedical applications due to their unique characteristics such as drug solubility, stability, and preferential accumulation [267]. Nano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of Technology, Tumkur, Karnataka, 572103, India, Melbourne Integrative Genomics, School of BioSciences/School of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, 3010, Australia, School of Optometry, Indiana University, Bloomington, Indiana, 47405, USA, Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, Melbourne, VIC, 3001, Australia, Suresh Kumar Bhargava&Hemant Kumar Daima, Department of Chemistry, University of Massachusetts (UMass) Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA, Amity Institute of Biotechnology, Amity University Rajasthan, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, Rajasthan, 303002, India, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode, Tamil Nadu, 638401, India, You can also search for this author in Similarly, in an in vivo environment, many smaller proteins and intrinsic biomolecules bind non-specifically on the surface of nanoparticles, commonly known as Vromans effect [58], leading to changed identity of the whole nanosystem. Int. B 3(39), 77247733 (2015), J. Zhang et al., pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. These particles can selectively target human osteosarcoma cells and are capable of pH-responsive antitumor drug delivery. B Appl. 2017;37:1. Docetaxel-loaded galactosamine combined with polydopamine-modified nanoparticles synthesized from d-a-tocopherol polyethylene glycol 1000 succinate-poly(lactide) (Gal-pD-TPGS-PLA/NPs) were found to inhibit the growth of HepG2 cells more effectively than TPGS-PLA/NPs, pD-TPGS-PLA/NPs, and a clinically available docetaxel formulation (Taxotere). 3(1), 1 (2016), A. Wicki et al., Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. Biomacromolecules 14(8), 26012610 (2013), A. Jose et al., Temperature-sensitive liposomes for co-delivery of tamoxifen and imatinib for synergistic breast cancer treatment. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Likewise, ztrk et al., developed a PEF modified dendrimer-based drug delivery system targeting Flt-1 (a receptor for vascular endothelial growth factors (VEGF)) receptor to improve the therapeutic efficacy of gemcitabine in pancreatic cancer. Biomaterials 31(3), 438448 (2010), E.C. Target substrates can be surface molecules expressed in diseased cells, proteins, sugars or lipids present in the organs, molecules present (or secreted by tumor cells) in the microenvironment of the diseased cells or even the physicochemical environment in the vicinity [46]. Google Scholar, X. Gao et al., In vivo cancer targeting and imaging with semiconductor quantum dots. Furthermore, poor pharmacokinetic characteristics of anticancer drugs arising from poor solubility, stability, and metabolism pose different challenges of toxicity, inefficacy and limited bio-distribution. Eng. The efficient delivery of nanomaterials to the target tissues can be classified as passive and active targeting, as discussed below. The CFPAC-1 pancreatic adenocarcinoma cell viability decreased, indicating a PEGc polyamide amine-PEG dendrimers anti-cancer effect. FOIA Let us see a few disadvantages briefly. What are the disadvantages of using nanotechnology in water and Advances and Implications in Nanotechnology for Lung Cancer - PubMed Release 141(3), 320327 (2010), X. Huang et al., The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.
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